Upcoming Event: Oden Institute Seminar

Multiphysics Modeling for Clinical Decision Support in Pediatric Cardiology

Alison Marsden, Stanford University

Abstract

Congenital heart disease affects 1 in 100 infants and is the leading cause of infant mortality in the US. Computational modeling is particularly valuable in this heterogeneous and high-risk population because of the need for personalized treatment planning and predictive models. We will describe recent advances in cardiovascular finite element simulation methods with specific focus on 1) multi-physics cardiac simulations incorporating data-driven methods for accelerated simulation, electrophysiology, cardiac contraction, fluid structure interaction, and valves, 2) Bayesian and multi-fidelity methods for uncertainty-aware simulations, and 3) generation of synthetic vascular networks with application to 3D bioprinting and tissue perfusion. We will then discuss clinical application of these methods to congenital heart disease with particular focus on single ventricle patients. 

Finally, we will discuss how the open source SimVascular project provides a software ecosystem for developing and sharing new capabilities with the broader scientific community.

Biography

Alison Marsden is the Douglass M. and Nola Leishman Professor of Cardiovascular Disease in the Departments of Pediatrics and Bioengineering at Stanford University. From 2007-2015 she was a faculty member at UCSD. She graduated with a BSE degree from Princeton in 1998, and a PhD from Stanford Mechanical Engineering in 2005. She was a postdoctoral fellow at Stanford from 2005-07. She was the recipient of a Burroughs Wellcome Fund Career Award at the Scientific Interface in 2007, and an NSF CAREER award in 2011. She has been elected fellow of AIMBE, SIAM, APS, BMES, ASME, and AAAS. She is the 2023 recipient of the Van C. Mow medal from the ASME Bioengineering Division. She has published over 200 journal articles, and her research focuses on cardiovascular biomechanics and engineering methods to impact patient care in cardiac surgery and congenital heart disease.